Literature review - Polycythaemia Vera
Nicola Richards, Nichola H Lawrence, Indu Singh, Michelle Butina
Int. J. Bio. Lab. Sci 2021(10)2:112-123【PDF】
Polycythemia vera is a rare, acquired clonal disorder of the hematopoietic stem cells resulting in unregulated proliferation of erythropoiesis leading to an accumulation of red cells. The main complications of the disorder arise from hyperviscosity and an increased risk of thrombosis. In recent years, advances in next generation sequencing (NGS) techniques have identified promising targets to enable more accurate risk stratification of patients as well as targets for new classes of therapeutic drugs. This article aims to review the current research in this field to provide an overview of the key features of this disease.
Key words: Polycythemia vera, myeloproliferative neoplasms, erythrocytosis.