Review article: Comparative Analysis of MicroRNAs and Proteinuria Testing for Early Diagnosis of Pre-eclampsia
Vivian Gaiko, Patricia Tille
Abstract
Pre-eclampsia (PE) is a life-threatening condition affecting pregnant females worldwide. PE poses significant risks to maternal and fetal health, necessitating early detection for timely management. Traditional diagnostic methods like proteinuria testing face limitations in sensitivity and specificity. Proteinuria can occur in other medical conditions other than PE. To address the challenge in PE detection, microRNAs (miRNAs) are emerging as biomarkers for early diagnosis. MiRNAs are small non-coding molecules that regulate gene expression. MiRNAs play important roles in PE pathogenesis, with dysregulated expression implicated in the disease. The release of miRNAs into circulation offers non-invasive detection options. While challenges like variability in expression profiles exist, miRNAs offer higher sensitivity and specificity compared to proteinuria testing. Standardized protocols and miRNA biomarker panels are needed for routine clinical use. Integrating miRNA analysis into existing diagnostic protocols holds promise for improving the accuracy of PE diagnosis and facilitating timely intervention to improve maternal and fetal outcomes.
Keywords: Pre-eclampsia, miRNA’s, proteinuria, pregnancy
Int. J. Bio. Lab. Sci 2024(13)2:143-156 【PDF】